Inflammation in end-stage renal failure: could it be treated?

Inflammation in end-stage renal failure: could it be treated?

End-stage renal disease (ESRD) is characterized by an exceptional mortality rate, much of which is the result of cardiovascular disease (CVD). Although traditional risk factors are common in ESRD patients, they may not be sufficient alone to account for the high prevalence of CVD in this condition. Recent evidence demonstrates that chronic inflammation, a non-traditional risk factor which is ob...

Acidosis in end-stage renal failure.

K.M.L. Leunissen, MD, PhD, University Hospital Maastricht, Department of Internal Medicine, PO Box 5800, NL-6202 AZ Maastricht (The Netherlands) Acidosis has been identified as one of the uremic toxins. Renal acidosis may contribute to renal osteodystrophy [1] and decreased myocardial contractility [2]. Furthermore, animal experimental studies proved that acidosis plays a pivotal role in the ac...

Prevention of end stage renal failure.

mutual incomprehension is far from inevitable. Indeed, Popper demonstrates that in science competing paradigms may continue side by side for long periods of time, and that new paradigms do not obliterate old ones, but rather incorporate them into more successful models.7 Although the variously constructed models for the health service are political rather than scientific, the principle of adapt...

Hydrothorax and end-stage chronic renal failure.

(Cheat 1991; 99:1010-11) T he patient is a 63-year-old woman with end-stage renal failure due to analgesic nephropathy. This was diagnosed in January, 1986 during treatment for high grade lymphoma (parotidectomy and chemotherapy). In July, 1987 the serum creatinine level reached 915 micromolfL. A Tenckoffcatheter was inserted and continuous ambulatory peritoneal dialysis (CAPD) was started at a...

Optimum treatment of end-stage renal failure.